Mononuclear Cu(II) complex of an oxime ligand derived from N-Heterocyclic hydrazide: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity
By Zengin, Ali; Karaoğlu, Kaan; Emirik, Mustafa; Menteşe, Emre; Serbest, Kerim
Published in Journal of Molecular Structure
2019
Abstract
A new oxime derivative N-heterocyclic hydrazide ligand, N'-[(1E,2E)-2-(hydroxyimino)-1-methylpropylidene]-2-[(4-methyl-5-phenyl-4H-1,2,4-triazol-3-l)thio] acetohydrazide (1) and its mononuclear copper(II) complex (1a) have been synthesized and characterized by using IR, UV–Vis, NMR and MALDI-TOF mass spectrometry. DFT-based molecular orbital energy calculations and electrochemical behaviors of the compounds have been also studied to explain redox potential of the compounds. The catecholase-mimetic activity of the Cu(II) complex (1a) has been investigated by monitoring the formation of 3,5-di-tert-butyl-benzoquinone from 3,5-di-tert-butylcatechol. Irreversible electrochemical ring-closing of the ligand by oxidation is proposed. Electrochemical ring-closing reaction is shielded by the coordination of Cu(II) to the oxime moiety of the ligand and the title complex undergoes quasi-reversible oxidation and irreversible reduction. Under aerobic conditions, the title copper(II) complex behaves as an effective catalyst towards oxidation of 3,5-di-tert-butylcatechol to its corresponding quinone derivative in MeOH. The turnover number was found as 100.1 h−1.