A photosensitive surface capable of inducing electrophysiological changes in NG108-15 neurons
By Fei Huang and John Bladon and Ross C. Lagoy and Peter N. Shorrock Jr. and Marie Hronik-Tupaj and Christopher A. Zoto and Robert E. Connors and W. Grant McGimpsey and Peter Molnar and Stephen Lambert and Ann R. Rittenhouse and Christopher R. Lambert
Published in Acta Biomaterialia
2015
Abstract
Retinal prostheses promise to be a viable therapy for many forms of blindness. Direct stimulation of neurons using an organic light-sensitive, self-assembled monolayer surface offers a simple alternative to conventional semiconductor technology. For this purpose we have derivatized an indium tin oxide (ITO) substrate with the photosensitive dye, NK5962, using 3-(aminopropyl)trimethoxysilane (APTMS) as cross-linker. The surface was characterized through contact angle goniometry, electrochemical impedance spectroscopy, grazing angle infrared and ultraviolet