Enhanced amperometric detection of metronidazole in drug formulations and urine samples based on chitosan protected tetrasulfonated copper phthalocyanine thin-film modified glassy carbon electrode
By S. Meenakshi and K. Pandian and L.S. Jayakumari and S. Inbasekaran
Published in Materials Science and Engineering: C
2016
Abstract
An enhanced electrocatalytic reduction of metronidazole antibiotic drug molecule using chitosan protected tetrasulfonated copper phthalocyanine (Chit/CuTsPc) thin-film modified glassy carbon electrode (GCE) has been developed. An irreversible reduction occurs at ? 0.47 V (vs. Ag/AgCl) using Chit/CuTsPc modified GCE. A maximum peak current value is obtained at pH 1 and the electrochemical reduction reaction is a diffusion controlled one. The detection limit is found to be 0.41 nM from differential pulse voltammetry (DPV) method. This present investigation method is adopted for electrochemical detection of metronidazole in drug formulation and urine samples by using \DPV\ method.