Chain Dynamics Limit Electron Transfer from Electrode-Bound, Single-Stranded Oligonucleotides
By Dauphin-Ducharme, Philippe; Arroyo-Curr
Published in The Journal of Physical Chemistry C
Abstract
A wide range of new devices aimed at in vivo molecular detection and point-of-care diagnostics rely on binding-induced changes in electron-transfer kinetics from an electrode-attached, redox-reporter-modified oligonucleotide as their signaling mechanism. In an effort to better characterize the mechanisms underlying these sensors, we have measured the electron-transfer kinetics associated with surface-attached, single-stranded DNAs modified with a methylene blue redox reporter either at the chain